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An analysis of behavioural effects produced by drug‐induced changes of dopaminergic neurotransmission in the brain
Author(s) -
AHLENIUS SVEN
Publication year - 1979
Publication title -
scandinavian journal of psychology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.743
H-Index - 72
eISSN - 1467-9450
pISSN - 0036-5564
DOI - 10.1111/j.1467-9450.1979.tb00683.x
Subject(s) - apomorphine , neurotransmission , dopamine , amphetamine , postsynaptic potential , dopaminergic , psychology , neuroscience , dopamine receptor , inhibitory postsynaptic potential , serotonergic , pharmacology , receptor , medicine , serotonin
An excessive activation of postsynaptic dopamine receptors as induced by the administration of L‐dopa, d ‐amphetamine or apomorphine produce an abnormal behaviour characterized by a loss of inhibitory control over behaviour and an impairment of associative mechanisms. This is in contrast to the modulation of components of normal behaviour by the administration of lower doses of these drugs. It is further concluded that the administration of drugs which inhibit brain dopamine neurotransmission results in an inability to initiate voluntary movements without effects on associative mechanisms.