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SEQUENTIAL SEARCHING SCHEMES FOR AN OPTIMAL DOSAGE
Author(s) -
Wei LeeJen
Publication year - 1977
Publication title -
australian journal of statistics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.434
H-Index - 41
eISSN - 1467-842X
pISSN - 0004-9581
DOI - 10.1111/j.1467-842x.1977.tb01082.x
Subject(s) - computer science , dosage form , bayesian probability , mathematical optimization , mathematics , statistics , pharmacology , medicine
For a certain chemotherapy an optimal dosage is defined as the highest possible dose which is still not “too toxic.” A linear regression is assumed between toxicity and dosage. Sequential searching processes for an optimal dosage are proposed utilizing Bayesian techniques. Simulations are performed to indicate the effectiveness of the new schemes.