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Duchenne muscle activity evaluation and muscle function preservation: is it possible a prophylactic strategy?
Author(s) -
Palmieri B.,
Sblendorio V.,
Ferrari A.,
Pietrobelli A.
Publication year - 2008
Publication title -
obesity reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.845
H-Index - 162
eISSN - 1467-789X
pISSN - 1467-7881
DOI - 10.1111/j.1467-789x.2007.00423.x
Subject(s) - exercise prescription , duchenne muscular dystrophy , medicine , muscle weakness , physical medicine and rehabilitation , weakness , muscle mass , disease , physical therapy , muscular dystrophy , energy expenditure , surgery
Summary Duchenne muscular dystrophy yields pervasive and progressive muscle mass loss. In the current measures relating to the monitoring of disease progression the following are relevant (i): the type of scale used, (ii) the clinical significance of the attribute being measured and (iii) the mathematical properties of the data provided. The high prevalence of obesity at an early stage of this pathology could result not only from reduced physical activity, but also from low resting energy expenditure, abnormal nutrient utilization or overfeeding. This muscle weakness may be attenuated by regular low‐intensity exercise. However, there is a critical lack of data to support appropriate exercise prescription. Because inappropriate activity may exacerbate the dystrophic process, a systematic analysis of muscle function to determine potential exercise load thresholds to avoid injury in dystrophic mice and dogs, and then in humans is recommended.