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Polymorphisms in adiponectin receptor genes ADIPOR1 and ADIPOR2 and insulin resistance
Author(s) -
Crimmins N. A.,
Martin L. J.
Publication year - 2007
Publication title -
obesity reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.845
H-Index - 162
eISSN - 1467-789X
pISSN - 1467-7881
DOI - 10.1111/j.1467-789x.2007.00348.x
Subject(s) - adiponectin , insulin resistance , adiponectin receptor 1 , insulin sensitivity , type 2 diabetes , insulin receptor , medicine , endocrinology , polymorphism (computer science) , insulin , genome wide association study , genetic association , gene , receptor , diabetes mellitus , biology , genetics , single nucleotide polymorphism , allele , genotype
Summary Adiponectin plays an important role in insulin sensitivity via adiponectin receptor 1 and 2 signalling. To date, six genetic association studies have examined the role of polymorphisms in the adiponectin receptor 1 and 2 genes (ADIPOR1 and ADIPOR2) in insulin resistance and type 2 diabetes. These studies are summarized in this review along with unpublished data from the authors. In addition, these polymorphism studies are used to illustrate some of the potential pitfalls and reasons for poor reproducibility of findings in genetic association studies.