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The role of chronic hypoxia in the development of neurocognitive abnormalities in preterm infants with bronchopulmonary dysplasia
Author(s) -
Raman Lakshmi,
Georgieff Michael K.,
Rao Raghavendra
Publication year - 2006
Publication title -
developmental science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.801
H-Index - 127
eISSN - 1467-7687
pISSN - 1363-755X
DOI - 10.1111/j.1467-7687.2006.00500.x
Subject(s) - bronchopulmonary dysplasia , neurocognitive , hypoxia (environmental) , neurochemical , psychology , dysplasia , cognition , medicine , neuroscience , pathology , gestational age , pregnancy , chemistry , genetics , organic chemistry , oxygen , biology
Bronchopulmonary dysplasia is the most common pulmonary morbidity in preterm infants and is associated with chronic hypoxia. Animal studies have demonstrated structural, neurochemical and functional alterations due to chronic hypoxia in the developing brain. Long‐term impairments in visual‐motor, gross and fine motor, articulation, reading, mathematics, spatial memory and attention skills are prevalent in survivors of bronchopulmonary dysplasia, and impairments appear to correlate with the severity of hypoxia. However, due to the simultaneous occurrence of multiple neurodevelopmental risk factors, a primary or potentiating role for chronic hypoxia in these impairments has yet to be conclusively established.