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Brain and cognitive‐behavioural development after asphyxia at term birth
Author(s) -
De Haan Michelle,
Wyatt John S.,
Roth Simon,
VarghaKhadem Faraneh,
Gadian David,
Mishkin Mortimer
Publication year - 2006
Publication title -
developmental science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.801
H-Index - 127
eISSN - 1467-7687
pISSN - 1363-755X
DOI - 10.1111/j.1467-7687.2006.00499.x
Subject(s) - asphyxia , psychology , cognition , brain damage , schizophrenia (object oriented programming) , term (time) , developmental psychology , neuroscience , psychiatry , medicine , pediatrics , physics , quantum mechanics
Perinatal asphyxia occurs in approximately 1–6 per 1000 live full‐term births. Different patterns of brain damage can result, though the relation of these patterns to long‐term cognitive‐behavioural outcome remains under investigation. The hippocampus is one brain region that can be damaged (typically not in isolation), and this site of damage has been implicated in two different long‐term outcomes, cognitive memory impairment and the psychiatric disorder schizophrenia. Factors in addition to the acute episode of asphyxia likely contribute to these specific outcomes, making prediction difficult. Future studies that better document long‐term cognitive‐behavioural outcome, quantitatively identify patterns of brain injury over development and consider additional variables that may modulate the impact of asphyxia on cognitive and behavioural function will forward the goals of predicting long‐term outcome and understanding the mechanisms by which it unfolds.