Open AccessProduction and glycosylation of plant‐made pharmaceuticals: the antibodies as a challenge
Author(s) -
Gomord Véronique,
Sourrouille Christophe,
Fitchette AnneCatherine,
Bardor Muriel,
Pagny Sophie,
Lerouge Patrice,
Faye Loïc
Publication year - 2004
Publication title -
plant biotechnology journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.525
H-Index - 115
eISSN - 1467-7652
pISSN - 1467-7644
DOI - 10.1111/j.1467-7652.2004.00062.x
Subject(s) - biology , monoclonal antibody , glycosylation , transgene , antibody , genetically modified crops , microbiology and biotechnology , production (economics) , computational biology , immunology , biochemistry , gene , macroeconomics , economics
Summary Antibodies have long been recognized for their diagnostic and therapeutic potential. The rapidly increasing number of monoclonal antibodies approved for immunotherapy has paved the way to an even greater demand for these molecules. In order to satisfy this growing demand and to increase the production capacity, alternative systems based on antibody production in transgenic organisms are being actively explored. In this paper, we focus on transgenic plants as a promising system for the scale‐up and processing of plant‐made pharmaceuticals. In particular, we point out the advantages and limitations induced by glycosylation of plant‐made antibodies for human therapy.