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A simple experimental method to study depigmenting agents
Author(s) -
Abella M. L.,
De Rigal J.,
Neveux S.
Publication year - 2007
Publication title -
international journal of cosmetic science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.532
H-Index - 62
eISSN - 1468-2494
pISSN - 0142-5463
DOI - 10.1111/j.1467-2494.2007.00385.x
Subject(s) - ellagic acid , colorimeter , medicine , mathematics , dermatology , chemistry , physics , biochemistry , polyphenol , quantum mechanics , antioxidant
Synopsis The first objective of the study was to verify that a controlled UV exposure of four areas of the forearms together with randomized product application enabled to compare treatment efficacy and then to compare the depigmenting efficacy of different products with a simple experimental method. Sixteen volunteers received 0.7 minimal erythermal dose for four consecutive days. Products tested were ellagic acid (0.5%), vitamin C (5%) and C8‐LHA (2%). Product application started 72 h post last exposure, was repeated for 42 days, the control zone being exposed, non‐treated. Colour measurements included Chromameter ® , Chromasphere ® , Spectro‐colorimeter and visual assessment. Comparison of colour values at day 1 and at day 7 showed that all zones were comparably tanned, allowing a rigorous comparison of the treatments. We report a new simple experimental model, which enables the rapid comparison of different depigmenting products. The efficacy and good tolerance of C8‐LHA make it an excellent candidate for the treatment of hyperpigmentory disorders.