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Stabilization and application of liposomal structures containing sphingomyelin
Author(s) -
Kaise C.,
Kaneko T.
Publication year - 2007
Publication title -
international journal of cosmetic science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.532
H-Index - 62
eISSN - 1468-2494
pISSN - 0142-5463
DOI - 10.1111/j.1467-2494.2007.00376_2.x
Subject(s) - sphingomyelin , liposome , lecithin , stratum corneum , glycerophospholipid , chemistry , sphingosine , ceramide , sphingolipid , bilayer , lipid bilayer , biochemistry , membrane , phospholipid , biology , apoptosis , genetics , receptor
Cosmetic products with high affinity to the skin have been recently studied, applying liposome and nano‐sized capsules formed by amphiphiles such as lecithin and other lipids to them. Sphingolipid, based on the sphingosine framework among the said lipids, is one of new bio‐lipids which have begun to be studied in terms of physicochemical/biological properties and applicabilities. Sphingomyelin is known as a representative sphingophospholipid. In this study, we tried to use this sphingomyelin as a cosmetic ingredient, particularly for a liposomal formula consisting of the sphingomyelin. As a result, it was found that its barrier (occlusive) ability against water evaporation was superior to that of lecithin as a representative glycerophospholipid, due to a higher rigidity in the bilayer membrane of the liposome. Therefore, it is expected that sphingomyelin will show a complementary effect for damaged intercellular lipid structures of the stratum corneum when it is applied to skin care products. In addition, it was demonstrated that a skin care product with sphingomyelin had a high moisturizing/emollient ability and an improvement effect on existing wrinkles.