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A new covalently bound ceramide from human stratum corneum – ω ‐hydroxyacylphytosphingosine
Author(s) -
Hill J.,
Paslin D.,
Wertz P. W.
Publication year - 2006
Publication title -
international journal of cosmetic science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.532
H-Index - 62
eISSN - 1468-2494
pISSN - 0142-5463
DOI - 10.1111/j.1467-2494.2006.00324.x
Subject(s) - stratum corneum , corneocyte , ceramide , chemistry , shampoo , keratin , covalent bond , penetration (warfare) , biochemistry , biophysics , chromatography , organic chemistry , biology , apoptosis , paleontology , genetics , operations research , engineering
Synopsis The outermost layer of the skin, the stratum corneum, consists of non‐viable keratin‐filled cells, or corneocytes, embedded in a matrix of lipids. The boundary of the cells consists of cross‐linked proteins with covalently bound lipids on the outer surface. The spaces between cells are filled with a mixture of ceramides, cholesterol and fatty acids. The stratum corneum provides a protective barrier against water loss through the skin and limits the penetration of potentially harmful substances from the environment. Among the covalently bound lipids on the corneocyte surface are ω ‐hydroxyacylsphingosine and ω ‐hydroxyacyl‐6‐hydroxysphingosine. The previously suspected presence of ω ‐hydroxyacylphytosphingosine is confirmed in this report through its specific isolation and characterization based on chromatographic behaviour and proton magnetic resonance spectral data.