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Technological strategies to improve photostability of a sunscreen agent
Author(s) -
Perugini P.,
Vettor M.,
Tursilli R.,
Scalia S.,
Genta I.,
Modena T.,
Pavanetto F.,
Conti B.
Publication year - 2006
Publication title -
international journal of cosmetic science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.532
H-Index - 62
eISSN - 1468-2494
pISSN - 0142-5463
DOI - 10.1111/j.1467-2494.2006.00307_5.x
Subject(s) - emulsion , chemistry , nanoparticle , uv filter , degradation (telecommunications) , chemical engineering , nanotechnology , materials science , organic chemistry , computer science , telecommunications , physics , engineering , optics
Due to the reduction of the ozone layer, there is an increasing need of effective UV protection systems with minimized side‐effects. Trans‐2‐ethylhexyl‐ p ‐methoxycinnamate ( trans ‐EHMC) represents one of the most widely used sunscreen compound. Several studies demonstrated that trans ‐EHMC is unstable following UV irradiation both in solution and in emulsion formulations. Moreover, various reports of photocontact sensitization induced by trans ‐EHMC have appeared in the literature. Consequently, in order to ensure adequate efficacy and safety for this sunscreen agent, there is a need for new carrier systems to enhance trans ‐EHMC photostability. In the present study the photostability of the filter in different formulation types (emulsion–gel, gel and emulsion) with various ingredients is evaluated. In addition, nanoparticles based on poly‐ D , L ‐lactide‐co‐glycolide (PLGA) as carrier for trans ‐EHMC are investigated. The influence of nanoparticle matrix on the photochemical stability of the sunscreen agent is also presented. The results obtained demonstrated that PLGA nanoparticles are effective in reducing the light‐induced degradation of the sunscreen agent. Moreover, the choice of formulation type and the excipients used play an important role in order to obtain a stable cosmetic product containing trans ‐EHMC.