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Simultaneous determination of chlorinated bacteriostats in cosmetic and pharmaceutical products
Author(s) -
Wang L.H.,
Tso M.,
Chin C.Y.
Publication year - 2005
Publication title -
international journal of cosmetic science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.532
H-Index - 62
eISSN - 1468-2494
pISSN - 0142-5463
DOI - 10.1111/j.1467-2494.2005.00289_4.x
Subject(s) - triclocarban , triclosan , chemistry , chromatography , elution , acetonitrile , cosmetics , organic chemistry , medicine , pathology
A high‐performance liquid chromatography method has been developed for simultaneous determination of triclosan (2,4,4‐trichloro‐2‐hydroxydiphenyl ether) and triclocarban (3,4,4‐trichlorocarbanilide) in cosmetic and pharmaceutical products. The two compounds could be separated on a Nucleosil C18 column and eluted with acetonitrile and water (70:30, v/v) as the mobile phase and detected with a differential refractive index detector. The retention times of triclosan and triclocarban were 5.81 and 2.99 min, respectively. The results obtained were in good agreement with those obtained by a differential pulse voltammetric method.