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Nicotinamide – biologic actions of an emerging cosmetic ingredient
Author(s) -
Otte N.,
Borelli C.,
Korting H. C.
Publication year - 2005
Publication title -
international journal of cosmetic science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.532
H-Index - 62
eISSN - 1468-2494
pISSN - 0142-5463
DOI - 10.1111/j.1467-2494.2005.00266.x
Subject(s) - nicotinamide , niacinamide , nicotinamide adenine dinucleotide , pellagra , cofactor , niacin , chemistry , biochemistry , nicotinamide adenine dinucleotide phosphate , pharmacology , medicine , enzyme , nad+ kinase , dermatology , oxidase test
Synopsis Nicotinamide, the water‐soluble amide of nicotinic acid, is a component of the two most important coenzymes – nicotinamide adenine dinucleotide and nicotinamide adenine dinucleotide phosphate. Thus nicotinamide is involved in numerous oxidation–reduction reactions in mammalian biological systems. Nicotinamide essentially acts as an antioxidant. Most effects are exerted via poly‐adenosine diphosphate‐ribose polymerase inhibition. Thus nicotinamide increasingly gains interest in the prevention and treatment of several skin diseases. It is well established in the systemic therapy of pellagra, a deficiency disease linked to nicotinic acid, but with respect to topical use there is still a need for further evidence with respect to its manifold potential uses. Currently, its local use is established in the care of acne‐prone skin.