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Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin 1
Author(s) -
Robinson L. R.,
Fitzgerald N. C.,
Doughty D. G.,
Dawes N. C.,
Berge C. A.,
Bissett D. L.
Publication year - 2005
Publication title -
international journal of cosmetic science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.532
H-Index - 62
eISSN - 1468-2494
pISSN - 0142-5463
DOI - 10.1111/j.1467-2494.2005.00261.x
Subject(s) - moisturizer , wrinkle , dermatology , medicine , placebo , pentapeptide repeat , chemistry , food science , biochemistry , pathology , gerontology , peptide , alternative medicine
Synopsis The palmitoyl pentapeptide palmitoyl‐lysine‐threonine‐threonine‐lysine‐serine (pal‐KTTKS) is a synthetic material that was designed as a topical agent to stimulate collagen production and thus provide a skin anti‐wrinkle benefit. To determine if pal‐KTTKS is effective, the clinical study reported here was conducted. Caucasian female subjects ( n = 93, aged 35–55) participated in a 12‐week, double‐blind, placebo‐controlled, split‐face, left–right randomized clinical study assessing two topical products: moisturizer control product vs. the same moisturizer product containing 3 ppm pal‐KTTKS. Pal‐KTTKS was well tolerated by the skin and provided significant improvement vs. placebo control for reduction in wrinkles/fine lines by both quantitative technical and expert grader image analysis. In self‐assessments, subjects also reported significant fine line/wrinkle improvements and noted directional effects for other facial improvement parameters.