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Determination of phthalate esters in cosmetics by gas chromatography with flame ionization detection and mass spectrometric detection
Author(s) -
Chen Huiming,
Wang Chao,
Wang Xing,
Hao Nan,
Liu Juan
Publication year - 2005
Publication title -
international journal of cosmetic science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.532
H-Index - 62
eISSN - 1468-2494
pISSN - 0142-5463
DOI - 10.1111/j.1467-2494.2005.00249.x
Subject(s) - phthalate , chromatography , chemistry , diethyl phthalate , dimethyl phthalate , gas chromatography , flame ionization detector , detection limit , cosmetics , gas chromatography–mass spectrometry , dibutyl phthalate , mass spectrometry , organic chemistry
Synopsis A gas chromatography coupled with flame ionization detection (GC‐FID) and mass spectrometric detection (MSD) method was developed to determine the six kinds of phthalate esters [dimethyl phthalate (DMP), diethyl phthalate (DEP), di‐ n ‐butyl phthalate (DBP), benzyl butyl phthalate (BBP), di(2‐ethylhexyl) phthalate (DEHP) and di‐ n ‐octyl phthalate (DOP)] in cosmetics (solid, cream and liquid cosmetics). The cosmetics were extracted with methanol by ultrasonic and then separated with high‐speed centrifugation. The upper clear layer was dried and filtered through a 0.45 μ m pore diameter filter. The filtrate was injected into GC‐FID/GC‐MS for detection. GC‐FID chromatogram was applied for qualitative analysis, external standard method was used for quantitative analysis. Confirmation of phthalate presence was undertaken by GC‐EI‐MS. The recovery range of all phthalates were between 92.0 and 110.0% with relative standard deviations between 1.95 and 5.92%. The low detection limits of the method were: 0.1 ng for DMP, DEP, DBP and BBP, 0.5 ng for DEHP and DOP. The method had advantages of high precision and sensitivity, simplicity of pretreatment. The method can be used to test the six kinds of phthalate esters in cosmetics.