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Zinc and titanium oxides: promising UV‐absorbers but what influence do they have on the intact skin?
Author(s) -
LANSDOWN A.B.G.,
TAYLOR A.
Publication year - 1997
Publication title -
international journal of cosmetic science
Language(s) - French
Resource type - Journals
SCImago Journal Rank - 0.532
H-Index - 62
eISSN - 1468-2494
pISSN - 0142-5463
DOI - 10.1111/j.1467-2494.1997.tb00180.x
Subject(s) - zinc , chemistry , nuclear chemistry , polyethylene glycol , metal , polymer chemistry , organic chemistry
Suspensions (20%) of microfine and ACS grade zinc oxide, or 20% titanium oxide in water, castor oil or polyethylene glycol were applied topically to rabbit skin over 4 h (1 day) or 2 h daily (3 days). Skin sites were analysed for metal uptake. Percutaneous absorption of the oxides was probably low, most remaining on the skin surface. Uptake patterns were influenced by the vehicles used. Appreciably more microfine zinc oxide was taken up by the skin in subacute studies. Local changes in trace metal concentration were construed as evidence of percutaneous absorption of zinc and titanium oxides. Further studies are indicated to validate the significance of these preliminary observations. On a applique superficiellement a de la peau de lapin des suspensions a 20% d'oxyde de zinc de qualite microfine ou ACS, ou a 20% d'oxyde de titane dans l'eau, l'huile de castor ou le polyethylene glycol, durant 4 heures (1 jour) ou 2 heures par jour (3 jours). On a analyse l'absorption de metal par la peau. L'absorption transcutanee des oxydes est probablement faible, la majeure partie restant en surface. Le deroulement de l'absorption est influence par le vecteur utilise. On constate que notablement plus d'oxyde de zinc microfin est absorbe par la peau dans les etudes subaigues. Les modifications locales dans la concentration des traces de metal ont ete interpretees comme des preuves d'absorption transcutanee d'oxydes de zinc et de titane. Des etudes ulterieures sont necessaires pour valider la signification de ces observations preliminaires.