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A screening procedure for total N ‐nitroso contaminants in personal care products: results of collaborative studies undertaken by a CTPA Working Group
Author(s) -
CHALLIS B.C.,
COLLING J.,
CROMIE D.D.O.,
GUTHRIE W.G.,
POLLOCK J.R.A.,
TAYLOR P.,
TELLING G.M.,
WALLACE L.
Publication year - 1995
Publication title -
international journal of cosmetic science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.532
H-Index - 62
eISSN - 1468-2494
pISSN - 0142-5463
DOI - 10.1111/j.1467-2494.1995.tb00127.x
Subject(s) - chemistry , nitrite , nitroso compounds , acetic acid , nitroso , solvent , nitric oxide , detection limit , chromatography , nitric acid , aqueous solution , chemiluminescence , nuclear chemistry , organic chemistry , nitrate
Synopsis A modified procedure for the determination of total N ‐nitroso compounds in personal care products was evaluated in collaborative studies organized through the UK Cosmetic Toiletry and Perfumery Association (CTPA). The method offers a true ‘totals’determination in that a solution of the whole sample is analysed. Samples are dissolved/suspended in water or aqueous THF, and nitrite/nitrite ester interferences are removed by prior treatment with sulphamic acid. The treated test solution is denitrosated in a single reaction with HBr/acetic acid, in refluxing n ‐propyl acetate, and ‘total’ N ‐nitroso compounds are determined in a chemiluminescence reaction of the released nitric oxide with ozone. The use of a propyl acetate denitrosation solvent and of higher concentrations of HBr have improved both the sensitivity (routine limit of determination at 10 μgkg ‐1 ) and water tolerance of the method. The method was shown to recover N ‐nitrosamines quantitatively, and to be sufficiently repeatable and reproducible to be used as a screening technique for N ‐nitroso compounds in personal care products.