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Prediction of the percutaneous penetration of ultra‐violet filters used in sunscreen formulations
Author(s) -
WATKINSON A.C.,
BRAIN K.R.,
WALTERS K.A.,
HADGRAFT J.
Publication year - 1992
Publication title -
international journal of cosmetic science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.532
H-Index - 62
eISSN - 1468-2494
pISSN - 0142-5463
DOI - 10.1111/j.1467-2494.1992.tb00059.x
Subject(s) - penetration (warfare) , systemic circulation , ultra violet , transdermal , human skin , penetration rate , biomedical engineering , chromatography , chemistry , materials science , medicine , mathematics , biology , pharmacology , engineering , petroleum engineering , optoelectronics , operations research , genetics
Synopsis The application of a mathematical model to estimate the extent of transdermal absorption of UV‐filters commonly used in sunscreen formulations is described. Percutaneous penetration is not a factor that has been properly addressed in the literature and the penetration/time profiles generated here suggest that significant amounts of certain of these compounds may penetrate the skin and enter the systemic circulation. The results presented indicate that further research in this area is necessary and the authors suggest that in vitro experiments with human skin are conducted with both current and new UV filters to quantify the degree of dermal penetration of these substances.

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