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Physico—chemical modifications of liposome structures through interaction with surfactantsy ‡
Author(s) -
RIBOSA I.,
GARCIA M.T.,
PARRA J.L.,
MAZA A.,
SANCHEZLEAL J.,
TRULLAS C.,
TSI A.,
BALAGUER F.,
PELEJERO C.
Publication year - 1992
Publication title -
international journal of cosmetic science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.532
H-Index - 62
eISSN - 1468-2494
pISSN - 0142-5463
DOI - 10.1111/j.1467-2494.1992.tb00048.x
Subject(s) - pulmonary surfactant , phospholipid , micelle , chemistry , vesicle , sodium dodecyl sulfate , bilayer , liposome , bromide , chromatography , nuclear chemistry , analytical chemistry (journal) , organic chemistry , aqueous solution , membrane , biochemistry
Synopsis The liposome‐surfactant interaction has been studied in this paper through the disrupting effect caused by surfactant molecules on large unilamellar vesicles prepared by reverse‐phase evaporation. This process leads, in the end, to the rupture of such structures and to the solubilization of the phospholipidic components, via mixed surfactant‐phospholipid micelle formation. This phenomenon is described by a three‐stage model and characterized by two parameters: the highest surfactant/phospholipid ratio that can exist in a vesicle ( R e sat ) and the lowest surfactant/phospholipid ratio required to keep the lipid and surfactant in the form of mixed micelles ( R e sat ). These parameters have been determined by spectrophotometry and 31 P NMR spectroscopy, obtaining results in a good agreement with both techniques. The surfactants tested have been: sodium dodecyl sulfate (SDS), sodium laurylether sulfate (SLES), N‐hexadecyl‐trimethylammonium bromide (HTAB), octylphenol series (8–20 EO) and alkylbetaines(C‐10, C‐12 and C‐14). Different R e sat and R e sol values have been obtained for each of the surfactants. This has permitted a study of the solubilizing capacity versus the phospholipidic bilayer of the different surfactants as a function of their structure.