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Dowicil 200 Stability test: chemical and microbiological studies
Author(s) -
SEMENZATO A.,
BENASSI C.A.,
ROSSI G.,
BETTERO A.,
LUCCHIARI M.,
CERINI R.
Publication year - 1990
Publication title -
international journal of cosmetic science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.532
H-Index - 62
eISSN - 1468-2494
pISSN - 0142-5463
DOI - 10.1111/j.1467-2494.1990.tb00541.x
Subject(s) - preservative , agar , formaldehyde , chromatography , chemistry , microbiology and biotechnology , food science , biology , bacteria , biochemistry , genetics
Synopsis The stability of the formaldehyde‐releaser preservative Dowicil 200 has been investigated. The studies were carried out on cosmetic emulsions preserved with different concentrations of Dowicil 200, stored in the dark at 45°C or 25°C. The degree of microbiological activity was tested with respect to S. aureus, P. aeruginosa, E. coli and A. niger using the agar diffusion and challenge tests. The chemical stability was evaluated by HPLC in the reverse phase mode. A significant preservative instability was observed.