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Activity of capryloyl collagenic acid against bacteria involved in acne
Author(s) -
FOURNIAT J.,
BOURLIOUX P.
Publication year - 1989
Publication title -
international journal of cosmetic science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.532
H-Index - 62
eISSN - 1468-2494
pISSN - 0142-5463
DOI - 10.1111/j.1467-2494.1989.tb00515.x
Subject(s) - bacteria , acne , microbiology and biotechnology , chemistry , food science , biology , medicine , dermatology , genetics
Synopsis Capryloyl collagenic acid (Lipacide C8Co) has similar bacteriostatic activity in vitro to that of benzoyl peroxide towards the bacteria found in acne lesions ( Staphylococcus aureus, Staphylococcus epidermidis and Propionibacterium acnes ) (MIC between 1 and 4 mg ml −1 for C8Co, and between 0.5 and 5 mg ml −1 for benzoyl peroxide). The presence of Emulgine M8 did not affect the bacteriostatic activity of C8Co. A 4% w/v solution of C8Co (incorporating Emulgine M8) fulfilled the criteria for an antiseptic preparation as laid down by the French Pharmacopoeia (10th Edition), and had a spectrum 5 bactericidal activity according to the French Standard AFNOR NF T 72–151. The excellent cutaneous tolerance of capryloyl collagenic acid would indicate that an aqueous solution might be of value for topical treatment of the bacterial component of acne.