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In vitro release of propranolol from oil/water microemuisions
Author(s) -
GASCO M. R.,
CARLOTTI M. E.,
TROTTA M.
Publication year - 1988
Publication title -
international journal of cosmetic science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.532
H-Index - 62
eISSN - 1468-2494
pISSN - 0142-5463
DOI - 10.1111/j.1467-2494.1988.tb00026.x
Subject(s) - propranolol , chemistry , pulmonary surfactant , microemulsion , lipophilicity , chromatography , nonionic surfactant , organic chemistry , biochemistry , medicine
Synopsis Oil/water (o/w) microemulsions containing propranolol were studied. Isopropylmyristate was used as the oil, Tween 60 as a surfactant, butanol as a co‐surfactant and a buffer of pH 6.5 for the continuous phase. The lipophilicity of propranolol was enhanced by formation of lipophilic ion‐pairs to obtain a disperse phase that could act as a reservoir; octanoic acid was used as counter‐ion. The diffusion rates of propranolol from microemulsions through a hydrophilic membrane decreased as the concentration of octanoic acid increased. The apparent permeability constant, determined at the beginning of the experiment, was 2.9 × 10 −9 cm s −1 for propranolol alone and diminished until 3.5 × 10 −10 cm s −1 in the presence of octanoic acid, at a concentration of 16.4 times that of propranolol.