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Screening tests of free radical scavengers for preventing sun‐accelerated cutaneous ageing
Author(s) -
BONNE C.,
MULLER A.,
GREGOIRE C.,
SINCHOLLE D.
Publication year - 1988
Publication title -
international journal of cosmetic science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.532
H-Index - 62
eISSN - 1468-2494
pISSN - 0142-5463
DOI - 10.1111/j.1467-2494.1988.tb00023.x
Subject(s) - scavenger , rose bengal , chemistry , ageing , thiobarbituric acid , free radical scavenger , skin aging , irradiation , free radical theory of aging , hydroxyl radical , skin reaction , epidermis (zoology) , radical , biophysics , biochemistry , dermatology , medicine , antioxidant , lipid peroxidation , biology , anatomy , organic chemistry , physics , nuclear physics
Synopsis Free radical formation has been shown to occur in UV‐irradiated skin and a large body of evidence suggests that these reactive agents are responsible for sun‐accelerated cutaneous ageing. The paper describes two tests for screening free radical scavengers potentially capable of inhibiting photo‐induced skin alterations. They are based on analysis of thiobarbituric acid‐reactive materials either in an acellular model in vitro or in the epidermis of rose bengal‐sensitized mice after white light irradiation. The tests were illustrated with silymarin, a potent vegetable free radical scavenger.