Premium
A comparison of the in vitro permeability properties of human and some laboratory animal skins
Author(s) -
SCOTT R. C.,
WALKER M.,
DUGARD P. H.
Publication year - 1986
Publication title -
international journal of cosmetic science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.532
H-Index - 62
eISSN - 1468-2494
pISSN - 0142-5463
DOI - 10.1111/j.1467-2494.1986.tb00446.x
Subject(s) - human skin , hairless , in vitro , chemistry , guinea pig , microbiology and biotechnology , biochemistry , biology , genetics , endocrinology
Synopsis The in vitro permeability of human and some common laboratory animals'skin has been measured to two chemicals with different physico‐chemical properties: [ 3 H] water, a small polar molecule and [ 14 C]paraquat dichloride (the ion), a fully ionised divalent cation. All the skins examined had similar permeabilities to [ 3 H]water: relative to human skin the greatest difference (x4.8) was measured through guinea pig skin. However, relative to human skin, all the animals were much more permeable to [ 14 C]paraquat, with factors of difference ranging between 40 (haired rat) and 1460 (hairless mouse). The in vitro technique allows the permeability of human and animal skin to be compared, facilitating extrapolation to Man of effects seen in animals during dermal exposure studies. Comparaison de la permeabilite in vitro de la peau humaine et de la peau de certains animaux de laboratoire