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Studies on the dermal toxicity of p‐phenylene diamine
Author(s) -
VISWANATHAN P. N.,
GUPTA V.,
MISRA V.
Publication year - 1985
Publication title -
international journal of cosmetic science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.532
H-Index - 62
eISSN - 1468-2494
pISSN - 0142-5463
DOI - 10.1111/j.1467-2494.1985.tb00415.x
Subject(s) - histamine , lipid peroxidation , toxicity , diamine , diamine oxidase , chemistry , superoxide dismutase , p phenylenediamine , guinea pig , biochemistry , pharmacology , antioxidant , medicine , endocrinology , enzyme , organic chemistry
Synopsis Single dermal application of p‐phenylene diamine in guinea‐pigs caused pathomorphological lesions over a period of 24 h which later disappeared. Lipid peroxidation activity of skin homogenate showed significant inhibition, whereas superoxide dismutase was unaffected. Histamine content increased initially but showed drastic reduction during recovery. The significance of the data in the potential dermal toxicity of hair dyes is discussed.