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Pedometer‐determined physical activity is linked to low systemic inflammation and low arterial stiffness in Type 2 diabetes
Author(s) -
Jennersjö P.,
Ludvigsson J.,
Länne T.,
Nystrom F. H.,
Ernerudh J.,
Östgren C. J.
Publication year - 2012
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.2012.03621.x
Subject(s) - medicine , pedometer , pulse wave velocity , arterial stiffness , interquartile range , type 2 diabetes , waist , blood pressure , diabetes mellitus , c reactive protein , endocrinology , cardiology , obesity , physical therapy , physical activity , inflammation
Diabet. Med. 29, 1119–1125 (2012) Abstract Aims The aim of this study was to explore the association between pedometer‐determined physical activity versus measures of obesity, inflammatory markers and arterial stiffness in people with Type 2 diabetes. Methods We analysed data from 224 men and 103 women with Type 2 diabetes, aged 54–66 years. Physical activity was measured with waist‐mounted pedometers during three consecutive days and the number of steps/day were calculated and classified in four groups: < 5000 steps/day, 5000–7499 steps/day, 7500–9999 steps/day and ≥ 10000 steps/day. Blood samples were analysed for lipids, HbA 1c , inflammatory markers including C‐reactive protein and interleukin‐6. Nurses measured blood pressure and anthropometrics. Aortic pulse wave velocity was measured with applanation tonometry over the carotid and femoral arteries. Results Mean steps/day was 7683 ± 3883 (median 7222, interquartile range 4869–10 343). There were no differences in age, diabetes duration, blood pressure, lipids or glycaemic control between the four groups of pedometer‐determined physical activity. Subjects with higher steps/day had lower BMI (28.8 vs. 31.5 kg/m 2 , P < 0.001), waist circumference (101.7 vs. 108.0 cm, P < 0.001), lower levels of C‐reactive protein (1.6 vs. 2.6 mg/l, P = 0.007), lower levels of interleukin‐6 (1.9 vs. 3.8 pg ml, P < 0.001) and lower pulse wave velocity (10.2 vs. 11.0 m/s, P = 0.009) compared with less physically active people. Conclusions We conclude that physical activity measured with pedometer was associated not only with less abdominal obesity, but also with decreased systemic low‐grade inflammation as well as with low arterial stiffness, in people with Type 2 diabetes.