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HbA 1c and glucose intolerance in obese children and adolescents
Author(s) -
Lee H. S.,
Park H. K.,
Hwang J. S.
Publication year - 2012
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.2012.03596.x
Subject(s) - medicine , impaired glucose tolerance , receiver operating characteristic , overweight , diabetes mellitus , percentile , glucose tolerance test , obesity , area under the curve , endocrinology , childhood obesity , impaired fasting glucose , type 2 diabetes , pediatrics , insulin resistance , statistics , mathematics
Diabet. Med. 29, e102–e105 (2012) Abstract Aims Childhood obesity is associated with an increased likelihood for having impaired glucose tolerance, dyslipidaemia and diabetes. The aim of the study was to evaluate HbA 1c as a screening test for impaired glucose tolerance in obese children and adolescents and identify the optimal HbA 1c threshold. Methods We studied 126 obese and overweight children (BMI > 85th percentile for age and gender) 4–17 years of age referred to the endocrine clinic at Ajou University Hospital in Korea. All subjects underwent HbA 1c and oral glucose tolerance test. Results Thirty‐four patients (27%) out of 126 had impaired glucose tolerance. Silent diabetes was diagnosed in 10 adolescents (7.9%). Based on the receiver operating characteristic curve, the optimal cut point of HbA 1c related to impaired glucose tolerance diagnosed by oral glucose tolerance test was 40 mmol/mol (5.8%), which was associated with a 64.7% sensitivity and 61.6% specificity, with an area under the receiver operating characteristic curve of 0.651 (95% CI 0.529–0.772). Conclusions Obesity is associated with an increased risk of impaired glucose tolerance. An HbA 1c value of 40 mmol/mol (5.8%) should be used as a screening tool to identify children and adolescents with impaired glucose tolerance.