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Effect of exposure to non‐esterified fatty acid on progressive deterioration of insulin secretion in patients with Type 2 diabetes: a long‐term follow‐up study
Author(s) -
Morita S.,
Shimajiri Y.,
Sakagashira S.,
Furuta M.,
Sanke T.
Publication year - 2012
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.2011.03566.x
Subject(s) - medicine , diabetes mellitus , type 2 diabetes , insulin , endocrinology , term (time) , secretion , fatty acid , biochemistry , chemistry , physics , quantum mechanics
Diabet. Med. 29, 980–985 (2012) Abstract Aim The aim of the study was to determine whether fasting serum non‐esterified fatty acid (NEFA) could be associated with long‐term progressive deterioration of insulin secretion in patients with Type 2 diabetes. Methods Seventy‐seven Japanese patients with Type 2 diabetes (mean BMI 23.3 kg/m 2 ) were followed for 10 years. We measured fasting C‐peptide level every 1–2 years. By using the slope of regression line between fasting C‐peptide level and duration, we calculated its individual annual decline as an index of insulin secretion. During the follow‐up periods of C‐peptide, the patients were evaluated for fasting serum non‐esterified fatty acid, LDL cholesterol, HDL cholesterol and HbA 1c levels for the last 8 years. We excluded patients who had renal dysfunction or anti‐insulin antibodies from among the insulin‐treated patients. Association between the individual annual decline of fasting C‐peptide level and related factors were evaluated. Results The mean individual annual decline of fasting serum C‐peptide level was −0.013 ± 0.027 nmol/l/year. Fasting serum non‐esterified fatty acid level had no significant difference between the first and the last 2 years of the 8‐year observation period of non‐esterified fatty acid. Using multiple regression analysis, mean fasting serum non‐esterified fatty acid level was associated with the individual annual decline of fasting serum C‐peptide level (standardized regression coefficient −0.358, P = 0.0056), although other related factors, including HbA 1c level, were not associated. Conclusions Mean fasting serum non‐esterified fatty acid level during an 8‐year observation was independently associated with long‐term progressive deterioration of insulin secretion in Japanese patients with Type 2 diabetes.