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Increased serum concentrations of adhesion molecules but not of chemokines in patients with Type 2 diabetes compared with patients with Type 1 diabetes and latent autoimmune diabetes in adult age: Action LADA 5
Author(s) -
Pham M. N.,
Hawa M. I.,
Roden M.,
Schernthaner G.,
Pozzilli P.,
Buzzetti R.,
Scherbaum W. A.,
Seissler J.,
Hunter S.,
Leslie R. D. G.,
Kolb H.,
Schloot N. C.
Publication year - 2012
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.2011.03546.x
Subject(s) - medicine , diabetes mellitus , type 2 diabetes , type 1 diabetes , endocrinology , chemokine , immunology , inflammation
Diabet. Med. 29, 470–478 (2012) Abstract Aims Systemic concentrations of adhesion molecules and chemokines are associated with increased risk of cardiovascular complications. We compared these factors between patients with Type 2 diabetes vs. Type 1 diabetes or latent autoimmune diabetes in adults. Methods Serum concentrations of adhesion molecules sE‐selectin, sICAM‐1 and sVCAM‐1, and chemokines CCL2, CCL3 and CCL4 were measured in 61 patients with latent autoimmune diabetes in adults, 90 with Type 1 diabetes, 465 with Type 2 diabetes and in 41 control subjects, using multiple regression models to adjust for possible confounders. Results Patients with Type 2 diabetes exhibited greater concentrations of adhesion molecules ( P < 0.02) than those with Type 1 diabetes, latent autoimmune diabetes in adults and control subjects. These differences persisted upon adjustments for age, sex, BMI, blood pressure and diabetes duration ( P < 0.04). Higher BMI positively correlated with concentrations of adhesion molecules in all subjects ( P < 0.0001). Concentrations of sE‐selectin positively related to diastolic (β = 0.31) and systolic (β = 0.28) blood pressure in the adjusted model ( P < 0.04). Concentrations of the chemokines, CCL2 and CCL4, did not differ between groups, while CCL3 was higher in patients with latent autoimmune diabetes in adults and Type 1 diabetes than in those with Type 2 diabetes and control subjects ( P < 0.05). Conclusions Systemic concentrations of adhesion molecules, but not chemokines, relate to cardiovascular risk factors, but remain higher after adjustments in Type 2 diabetes, suggesting a diabetes‐type specific effect without difference between latent autoimmune diabetes in adults and Type 1 diabetes, despite their dissimilar phenotype.