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Alcohol consumption and risk of pre‐diabetes and type 2 diabetes development in a Swedish population
Author(s) -
Cullmann M.,
Hilding A.,
Östenson C.G.
Publication year - 2012
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.2011.03450.x
Subject(s) - medicine , type 2 diabetes , diabetes mellitus , odds ratio , risk factor , confidence interval , binge drinking , population , cohort study , endocrinology , environmental health , poison control , injury prevention
Diabet. Med. 29, 441–452 (2012) Abstract Aims Alcohol is a potential risk factor of Type 2 diabetes. However, more detailed information on effects of alcohol types and early phases of Type 2 diabetes development seems warranted. The aim of this study was to investigate the influence of alcohol consumption and specific alcoholic beverages on the risk of developing pre‐diabetes and Type 2 diabetes in middle‐aged Swedish men and women. Methods Subjects, who at baseline had normal glucose tolerance (2070 men and 3058 women) or pre‐diabetes (70 men and 41 women), aged 35–56 years, were evaluated in this cohort study. Logistic regression was performed to estimate the risk [odds ratio (OR) and 95% confidence interval (CI)] to develop pre‐diabetes and Type 2 diabetes at 8–10 years follow‐up, in relation to self‐reported alcohol intake at baseline. Adjustment was performed for several risk factors. Results Total alcohol consumption and binge drinking increased the risk of pre‐diabetes and Type 2 diabetes in men (OR 1.42, 95% CI 1.00–2.03 and OR 1.67, 95% CI 1.11–2.50, respectively), while low consumption decreased diabetes risk in women (OR 0.41, 95% CI 0.22–0.79). Men showed higher risk of pre‐diabetes with high beer consumption (OR 1.84, 95% CI 1.13–3.01) and of Type 2 diabetes with high consumption of spirits (OR 2.03, 95% CI 1.27–3.24). Women showed a reduced risk of pre‐diabetes with high wine intake (OR 0.66, 95% CI 0.43–0.99) and of Type 2 diabetes with medium intake of both wine and spirits (OR 0.46, 95% CI 0.24–0.88 and OR 0.55, 95% CI 0.31–0.97, respectively), whereas high consumption of spirits increased the pre‐diabetes risk(OR 2.41, 95% CI 1.47–3.96). Conclusion High alcohol consumption increases the risk of abnormal glucose regulation in men. In women the associations are more complex: decreased risk with low or medium intake and increased risk with high alcohol intake.