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Measurement of insulin action: a tribute to Sir Harold Himsworth
Author(s) -
Kim S. H.
Publication year - 2011
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.2011.03409.x
Subject(s) - medicine , insulin , insulin sensitivity , tribute , diabetes mellitus , action (physics) , endocrinology , insulin resistance , art history , art , physics , quantum mechanics
Diabet. Med. 28, 1487–1493 (2011) Abstract Sir Harold Himsworth was a renowned clinician and researcher. Among his myriad of accomplishments, he was the first to differentiate diabetes mellitus into ‘insulin‐sensitive’ and ‘insulin‐insensitive’ forms. To help distinguish these two types, he developed the first test to measure insulin sensitivity, the insulin–glucose test. This article reviews Himsworth’s pioneer methods and subsequent advances in the measurement of insulin action. The advantages and limitations of commonly used methods to assess insulin sensitivity are also examined.