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Serum adiponectin, bone mineral density and bone turnover markers in post‐menopausal women with newly diagnosed Type 2 diabetes: a 12‐month follow‐up
Author(s) -
Miazgowski T.,
NoworytaZiętara M.,
Safranow K.,
Ziemak J.,
Widecka K.
Publication year - 2012
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.2011.03381.x
Subject(s) - medicine , adiponectin , bone mineral , bone remodeling , endocrinology , type 2 diabetes , diabetes mellitus , osteoporosis , insulin resistance
Diabet. Med. 29, 62–69 (2012) Abstract Objective During a period of 12 months, we evaluated the longitudinal impact of metabolic control of diabetes on selected bone turnover markers, bone mineral density and serum adiponectin concentrations in post‐menopausal women with newly diagnosed Type 2 diabetes. Methods Serum total adiponectin, bone alkaline phosphatase, HbA 1c , urinary deoxypyridinoline excretion, bone mineral density of the total body, lumbar spine and total hip were measured in 57 women aged 50–78 years with newly diagnosed Type 2 diabetes. Results At baseline, women had normal bone‐specific alkaline phosphatase, deoxypyridinoline and bone mineral density, as evaluated by t ‐ and z ‐scores. After 12 months of treatment, a significant decrease in body weight, waist circumference and HbA 1c was observed. Bone mineral density of the total body, lumbar spine and total hip decreased by 0.4, 0.2 and 1.0% ( P = 0.018) per year, respectively. Adiponectin was inversely correlated with bone mineral density at three sites ( R = −0.28, −0.24 and −0.19, respectively).There was a transient increase ( P < 0.05) in serum adiponectin within the first 6 months, followed by a slow decrease toward the baseline value during the next 6 months. An improvement in diabetes control had no impact on bone turnover marker levels, which did not change significantly during the entire study period. Conclusions Bone turnover markers, bone mineral density and the rate of bone loss are within normal ranges in post‐menopausal women with newly diagnosed Type 2 diabetes. Bone mineral density of the total body, lumbar spine and total hip is inversely correlated with total adiponectin.