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Effect of exercise intensity on albuminuria in adolescents with Type 1 diabetes mellitus
Author(s) -
Kornhauser C.,
Malacara J.M.,
MacíasCervantes M.H.,
RiveraCisneros A.E.
Publication year - 2012
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.2011.03380.x
Subject(s) - microalbuminuria , medicine , albuminuria , diabetes mellitus , metabolic control analysis , vo2 max , cardiology , type 1 diabetes , type 2 diabetes mellitus , type 2 diabetes , physical exercise , exercise intensity , endocrinology , blood pressure , heart rate
Diabet. Med. 29, 70–73 (2012) Abstract Aims Exercise may be useful to detect patients with diabetes prone to develop persistent microalbuminuria. We studied the relationship between exercise intensity, measured as maximal oxygen consumption (VO 2 max), and microalbuminuria in patients with Type 1 diabetes mellitus patients. Methods We studied 10 patients, age range 10–18 years, with Type 1 diabetes who were normotensive and normoalbuminuric, with less than 10 years since diagnosis. Patients had normal renal function, without infections or clinical evidence of complications. Metabolic control was intensively adjusted in all patients. They underwent three consecutive physical exercise tests, reaching 100, 80 and 60% of the maximal cardiac frequency response. Results Eight patients had adequate to regular metabolic control. All patients had lower than predicted VO 2 max values. At 60%, only three patients showed microalbuminuria in excess of 20 μg/min, two of them had inadequate metabolic control. Post‐exercise microalbuminuria exceeded normal values in nine, seven and three patients when submitted to 100, 80 and 60% of exercise intensity, respectively. Conclusions Microalbuminuria increased with exercise intensity. Sex, body composition and VO 2 max were the main factors associated with microalbuminuria. The prognostic significance of albuminuria induced by intense exercise in these subjects with Type 1 diabetes is not yet known.