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Serum omentin‐1 and chemerin levels are interrelated in patients with Type 2 diabetes mellitus with or without ischaemic heart disease
Author(s) -
ElMesallamy H. O.,
ElDerany M. O.,
Hamdy N. M.
Publication year - 2011
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.2011.03353.x
Subject(s) - chemerin , medicine , adipokine , insulin resistance , diabetes mellitus , endocrinology , type 2 diabetes , obesity , type 2 diabetes mellitus , insulin
Diabet. Med. 28, 1194–1200 (2011) Abstract Aims Omentin‐1 and chemerin have been identified as interesting novel adipokines that may modulate insulin action. Also, they have been suggested to be linked to obesity‐induced insulin resistance. The aim of this study was to analyse the relationship between these adipokines and interleukin‐6, insulin resistance and anthropometric and metabolic variables in patients with Type 2 diabetes mellitus and in patients with Type 2 diabetes who have ischaemic heart disease. Methods Seventy‐five individuals with Type 2 diabetes and 15 healthy control subjects were enrolled in this study. Insulin levels, interleukin‐6, omentin‐1 and chemerin were measured by ELISA. Results Serum omentin‐1 levels were found to be significantly decreased in patients with Type 2 diabetes (19.7 ± 1 ng/ml) and in patients with Type 2 diabetes with ischaemic heart disease (18.5 ± 1.6 ng/ml) compared with healthy control subjects (27.4 ± 2.6 ng/ml) at P < 0.01. Moreover, serum chemerin levels were found to be significantly increased in patients with Type 2 diabetes (347 ± 14 ng/ml) and in patients with Type 2 diabetes with ischaemic heart disease (341 ± 16.5 ng/ml) compared with healthy control subjects (281 ± 13 ng/ml) at P < 0.01. Interestingly, omentin‐1 and chemerin levels were found to be significantly correlated negatively with each other as well as being individually correlated with some selected anthropometric, biochemical and clinical variables. In conclusion, both omentin‐1 and chemerin might play as a pivotal role in obesity and its associated disorders as Type 2 diabetes; however, their role in cardiovascular diseases needs to be fully elucidated.