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A meta‐analysis of the association between pre‐eclampsia and childhood‐onset Type 1 diabetes mellitus
Author(s) -
Henry E. B.,
Patterson C. C.,
Cardwell C. R.
Publication year - 2011
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.2011.03291.x
Subject(s) - medicine , odds ratio , confidence interval , meta analysis , eclampsia , cohort study , type 1 diabetes , pregnancy , diabetes mellitus , type 2 diabetes , obstetrics , pediatrics , endocrinology , genetics , biology
Diabet. Med. 28, 900–905 (2011) Abstract Aims To review and synthesize the evidence for an increased risk of childhood Type 1 diabetes mellitus in children born to mothers diagnosed with pre‐eclampsia during pregnancy. Methods A comprehensive search of the published literature was performed in MEDLINE, Web of Science and EMBASE limited to studies published before August 2010. Crude odds ratios and 95% confidence intervals were calculated from the data reported in each study. Meta‐analysis techniques were then used to derive a combined odds ratio and investigate heterogeneity. Sensitivity analyses were conducted by study design, ascertainment of pre‐eclampsia and study quality. Results Data were available from 16 studies including 8315 children with Type 1 diabetes. Overall, there was little evidence of an increase in the risk of Type 1 diabetes in children born to mothers who had pre‐eclampsia during pregnancy (OR = 1.10, 95% CI 0.96–1.27; P = 0.17). This association did not vary much between studies ( I 2 = 28%, P for heterogeneity = 0.14). The association was similar in three cohort studies (OR = 1.05, 95% CI 0.77–1.44; P = 0.75) and in seven studies with a low risk of bias (OR = 1.13, 95% CI 0.91–1.40; P = 0.27), but was more marked in 13 studies which ascertained pre‐eclampsia from obstetrical records or birth registry data (OR = 1.18, 95% CI 1.03–1.36; P = 0.02). Conclusions This analysis demonstrates little evidence of any substantial increase in childhood Type 1 diabetes risk after pregnancy complicated by pre‐eclampsia.