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Age effect on vascular reactivity in Type 1 diabetes
Author(s) -
Grzelak P.,
Czupryniak L.,
Olszycki M.,
Majos A.,
Stefańczyk L.
Publication year - 2011
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.2011.03277.x
Subject(s) - medicine , diabetes mellitus , brachial artery , lumen (anatomy) , type 2 diabetes , hemodynamics , cardiology , diastole , artery , endocrinology , blood pressure
Diabet. Med. 28, 833–837 (2011) Abstract Aim The objective of this study was to assess the effect of age on vascular reactivity in patients with Type 1 diabetes. Methods Forty‐five patients with Type 1 diabetes and 71 healthy control subjects, divided into three age groups (18–30, 31–45 and 46–60 years old), underwent assessment of vascular reactivity based on ultrasound examination of a brachial artery after nitric oxide donor administration. Results The vasodilative and haemodynamic effect was most pronounced in the youngest control subjects, where lumen widening of 0.51 ± 0.16 mm (13.9 ± 4.2%) and increase in early velocity of 28.4 ± 6.5 cm/s (237 ± 55%) were observed, while, in the control subjects from the middle and oldest age groups, the increase in artery diameter was 0.4 ± 0.11 and 0.22 ± 0.12 mm (9.8 ± 2.6 and 5.0 ± 2.6%), respectively. In the youngest patients with diabetes, lumen widening by 0.35 ± 0.13 mm (8.6 ± 3.4%) and increase in early diastolic velocity by 16.9 ± 5.6 cm/s (158 ± 52%) were noted ( P < 0.05 vs. control subjects). In patients with diabetes from the middle and oldest age groups, the increase in artery diameter was 0.26 ± 0.06 and 0.16 ± 0.09 mm (5.5 ± 1.4 and 3.2 ± 1.8%), respectively. Conclusions Vascular reactivity is strongly age dependent in all subjects; however, responses are delayed and occur over a longer time period in the patients with diabetes. Vasodilation test protocols should take into account the age of the subjects.