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Plasma levels of glucagon like peptide‐1 associate with diastolic function in elderly men
Author(s) -
Nathanson D.,
Zethelius B.,
Berne C.,
Lind L.,
Andrén B.,
Ingelsson E.,
Holst J. J.,
Nyström T.
Publication year - 2011
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.2010.03207.x
Subject(s) - medicine , heart failure , diabetes mellitus , cardiology , impaired glucose tolerance , glucagon like peptide 1 , incidence (geometry) , endocrinology , glucose tolerance test , diastole , type 2 diabetes , insulin resistance , blood pressure , physics , optics
Diabet. Med. 28, 301–305 (2011) Abstract Aims Congestive heart failure is a major cause of morbidity and mortality in diabetes. Besides the glycaemic effects of glucagon‐like peptide 1 (GLP‐1) mimetics, their effects on the heart are of interest. Methods We aimed to investigate longitudinal relationships between plasma levels of fasting GLP‐1 (fGLP‐1), 60‐min oral glucose tolerance test‐stimulated GLP‐1 levels (60GLP‐1), and the dynamic GLP‐1 response after oral glucose tolerance test (ΔGLP‐1 = 60GLP‐1 – fGLP‐1) and incidence of hospitalized congestive heart failure, during a follow‐up time of a maximum of 9.8 years in 71‐year‐old men. We also investigated, cross‐sectionally, the association between GLP‐1 and left ventricular function as estimated by echocardiography. Results During the follow‐up period, 16 of 290 participants with normal glucose tolerance experienced a congestive heart failure event (rate 0.7/100 person‐years at risk), as did eight of 136 participants (rate 0.8/100 person‐years at risk) with impaired glucose tolerance and nine of 72 participants (rate 1.7/100 person‐years at risk) with Type 2 diabetes mellitus. Although GLP‐1 concentrations did not predict congestive heart failure (fGLP‐1: HR 0.98, 95% CI 0.4–2.4; 60GLP‐1: HR 1.1, 95% CI 0.4–2.6; ΔGLP‐1: HR 0.9, 95% CI 0.3–2.3), there was an association between left ventricular diastolic function (E/A ratio) and fGLP‐1 ( r = 0.19, P = 0.001), 60GLP‐1 ( r = 0.20, P < 0.001) and ΔGLP‐1 ( r = 0.18, P = 0.004). There was a lack of differences in plasma levels of GLP‐1 between the groups with Type 2 diabetes and normal glucose tolerance. Conclusions There were no longitudinal associations between GLP‐1 levels and incidence of hospitalization for congestive heart failure. However, without any causality proven, GLP‐1 levels did correlate, cross‐sectionally, with left ventricular diastolic function in this cohort, suggesting that pathways including GLP‐1 might be involved in the regulation of cardiac diastolic function.