Premium
The Chronic Kidney Disease Epidemiology Collaboration (CKD‐EPI) equation is less accurate in patients with Type 2 diabetes when compared with healthy individuals
Author(s) -
Camargo E. G.,
Soares A. A.,
Detanico A. B.,
Weinert L. S.,
Veronese F. V.,
Gomes E. C.,
Silveiro S. P.
Publication year - 2011
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.2010.03161.x
Subject(s) - medicine , renal function , kidney disease , diabetes mellitus , creatinine , type 2 diabetes , epidemiology , urology , endocrinology
Diabet. Med. 28, 90–95 (2011) Abstract Aims To analyse the performances of Chronic Kidney Disease Epidemiology Collaboration (CKD‐EPI) and of Modification of Diet in Renal Disease (MDRD) study equations to estimate glomerular filtration rate (GFR) in patients with Type 2 diabetes mellitus with GFRs >60 ml/min and in healthy volunteers. Methods This cross‐sectional study included 111 individuals (56 patients with Type 2 diabetes and 55 healthy volunteers), aged 58 ± 9 years; 54 individuals were men (49%) and ninety‐eight (88%) were white. Glomerular filtration rate was measured by the 51 Cr‐EDTA single‐injection method ( 51 Cr‐GFR) and estimated according to the standardized MDRD and CKD‐EPI equations. Serum creatinine was measured by a traceable Jaffe method. Bland–Altman analysis was used to examine the agreement between measured and estimated GFR. Bias, accuracy and precision were evaluated. Results In diabetic individuals, 51 Cr‐GFR was 106 ± 27 ml/min/1.73 m 2 , CKD‐EPI‐estimated GFR 82 ± 18 ml/min/1.73 m 2 and MDRD‐estimated GFR 80 ± 21 ml/min/1.73 m 2 ( P < 0.001). In healthy volunteers, the corresponding values were 98 ± 20, 89 ± 13 and 84 ± 14 ml/min/1.73 m 2 ( P < 0.001). The accuracy of CKD‐EPI (P30) was higher in healthy volunteers than in diabetic patients (90 vs. 66%, respectively, P < 0.001). The MDRD equation performed as poorly as the CKD‐EPI equation in individuals with Type 2 diabetes. Conclusions The CKD‐EPI equation is less accurate in patients with Type 2 diabetes when compared with healthy individuals, with a 2.5‐fold greater bias.