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Cigarette smoking and proteinuria in Taiwanese men with Type 2 diabetes mellitus
Author(s) -
Hsu C. C.,
Hwang S. J.,
Tai T. Y.,
Chen T.,
Huang M. C.,
Shin S. J.,
Wen C. P.,
Shih Y. T.,
Yang H. J.,
Chang C. T.,
Chang C. J.,
Loh C. H.,
Fuh M. T.,
Li Y. S.,
Chang H.Y.
Publication year - 2010
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.2010.02947.x
Subject(s) - medicine , proteinuria , diabetes mellitus , diabetic nephropathy , nephropathy , creatinine , risk factor , albuminuria , cohort , type 2 diabetes , urine , type 2 diabetes mellitus , logistic regression , endocrinology , kidney
Diabet. Med. 27, 295–302 (2010) Abstract Aims Cigarette smoking is a well‐known risk factor associated with diabetic nephropathy. The objective of this study was to further investigate the dose–response effect of tobacco exposure on proteinuria in males with Type 2 diabetes. Methods Five hundred and nine males with Type 2 diabetes were selected from a cohort participating in a glucose control study in Taiwan. Pack‐years of cigarette smoking were calculated to define tobacco exposure. Proteinuria was identified if albumin‐to‐creatinine ratio was ≥ 30 mg/g in at least two of three consecutive urine tests. Logistic regression and trend tests were used to delineate the association between smoking status and proteinuria. Results Compared with non‐smokers, those who had smoked 15–30 or more than 30 pack‐years were respectively 2.78 (95% CI 1.34–5.76, P < 0.01) and 3.20 (95% CI 1.74–5.86, P < 0.001) times more likely to develop proteinuria. The dose–response effect of tobacco exposure on the development of proteinuria is highly significant in all subjects ( P = 0.001) and in subgroups with relatively short duration of diabetes mellitus ( P < 0.001), good blood pressure control ( P = 0.001) and those of young age ( P = 0.007). Conclusions The current study shows a clear dose–response effect of cigarette smoking on development of proteinuria in male Type 2 diabetic patients. These findings reinforce the urgent need to encourage diabetic patients to stop smoking regardless of age, duration of diabetes mellitus or status of blood pressure control.