Premium
Plasma osteoprotegerin concentrations in peripheral sensory neuropathy in Type 1 and Type 2 diabetic patients
Author(s) -
Nybo M.,
Poulsen M. K.,
Grauslund J.,
Henriksen J. E.,
Rasmussen L. M.
Publication year - 2010
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.2010.02940.x
Subject(s) - medicine , osteoprotegerin , peripheral neuropathy , type 2 diabetes , peripheral , diabetes mellitus , endocrinology , receptor , activator (genetics)
Diabet. Med. 27, 289–294 (2010) Abstract Aims Osteoprotegerin (OPG) has been linked to different diabetes complications, including cardiovascular disease, and new findings have indicated a specific role in diabetic peripheral neuropathy, but the exact mechanism is unknown. To investigate a possible association between OPG and diabetic peripheral sensory neuropathy, we therefore analysed plasma OPG in Type 1 and Type 2 diabetic patients with and without peripheral neuropathy. Subjects and methods Two hundred Type 1 diabetes mellitus (T1DM) patients and 305 Type 2 diabetes mellitus (T2DM) patients participated in the study. Plasma OPG was measured with a sandwich immunoassay. Peripheral neuropathy was assessed by the Semmes–Weinstein monofilament test. Results In T2DM, plasma OPG concentrations were significantly higher in the peripheral neuropathy group ( P < 0.001). Furthermore, there was a significant relationship between the presence of neuropathy in T2DM and plasma OPG levels on logistic regression ( P = 0.006). However, when investigated in a full multiple regression model including other long‐term diabetes complications, the association became insignificant ( P = 0.092). In T1DM, the difference in plasma OPG between groups did not reach significance ( P = 0.066). However, plasma OPG significantly correlated to peripheral neuropathy in this group also ( P = 0.022), although this correlation was not significant in a multiple linear regression model ( P = 0.051). Conclusion Plasma OPG levels are related to peripheral neuropathy in both Type 1 and Type 2 diabetes, although with the strongest relationship in T2DM. Before understanding the significance of this, the pathological mechanism involved and, speculatively, a possible use of plasma OPG as a peripheral sensory neuropathy marker, a larger prospective study is needed.