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Effect of l ‐arginine on the microcirculation in the neuropathic diabetic foot in Type 2 diabetes mellitus: a double‐blind, placebo‐controlled study
Author(s) -
Jude E. B.,
Dang C.,
Boulton A. J. M.
Publication year - 2010
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.2009.02876.x
Subject(s) - medicine , microcirculation , diabetes mellitus , peripheral neuropathy , placebo , diabetic neuropathy , diabetic foot , vasodilation , endothelial dysfunction , randomized controlled trial , anesthesia , cardiology , surgery , endocrinology , pathology , alternative medicine
Diabet. Med. Abstract Objective To investigate the effect of l ‐arginine on endothelial function, transcutaneous oxygen and clinical neuropathy in patients with peripheral neuropathy as a result of diabetes. Research design and methods Thirty diabetic patients with peripheral neuropathy were randomized to receive l ‐arginine (3 g three times daily) or placebo (3 g three times daily) for 3 months. All patients had foot microcirculation and foot transcutaneous oxygen pressure (TcPO 2 ), neuropathy disability score (NDS) and vibration perception threshold (VPT) assessed at baseline and follow‐up. Results No difference was observed in endothelium‐dependent and ‐independent vasodilation, TcPO 2 , NDS and VPT. Conclusions l ‐arginine has no effect on endothelial dysfunction, TcPO 2 and clinical neuropathy.