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First trimester serum neutrophil gelatinase‐associated lipocalin in gestational diabetes
Author(s) -
D’Anna R.,
Baviera G.,
Corrado F.,
Giordano D.,
Recupero S.,
Di Benedetto A.
Publication year - 2009
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.2009.02830.x
Subject(s) - medicine , lipocalin , gestational diabetes , gestation , pregnancy , insulin resistance , diabetes mellitus , endocrinology , cohort , gestational age , obstetrics , biology , genetics
Aims Neutrophil gelatinase‐associated lipocalin (NGAL) is highly expressed in damaged epithelia, during inflammation and cardiovascular disease. Soluble NGAL was measured in women who subsequently developed gestational diabetes. Methods From a cohort of 908 pregnant outpatients who participated in a screening programme for Down’s syndrome at 9–12 weeks of gestation, we considered all 41 women with a singleton pregnancy, who developed gestational diabetes in the previous 12 months, and a control group of 82 normal pregnancies. Circulating NGAL and insulin resistance by homeostasis model assessment ratio (HOMA‐IR) were determined in the first trimester. Results Median serum NGAL concentrations were higher in the gestational diabetes group [51.3 ng/ml (39.8–66.1 ng/ml)] compared with the control group [17.8 ng/ml (15.5–20.9 ng/ml)] ( P < 0.001) and positively correlated with HOMA‐IR ( P < 0.001). Conclusions In the first trimester, circulating NGAL was significantly increased in women who subsequently developed gestational diabetes compared with the control group.