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Glycaemia‐independent ethnic differences in HbA 1c in subjects with impaired glucose tolerance
Author(s) -
Likhari T.,
Gama R.
Publication year - 2009
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.2009.02803.x
Subject(s) - medicine , impaired glucose tolerance , ethnic group , south asia , diabetes mellitus , ethnic origin , endocrinology , type 2 diabetes , population , ethnology , environmental health , sociology , anthropology , history
Aim To study the ethnic differences in HbA 1c between Whites and South Asians with impaired glucose tolerance. Methods We audited 75g oral glucose tolerance tests (OGTT) performed in Clinical Chemistry, New Cross Hospital, Wolverhampton over 1 year. HbA 1c and glycaemia were compared between Whites and South Asians with impaired glucose intolerance (IGT). Results There were 46 South Asians (22 female) and 88 Whites (41 female). South Asian subjects were younger (59.2 ± 14.31 vs. 67.6 ± 12.63 yrs; P < 0.001) and weighed less (78.1 ± 17.2 vs. 87.47 ± 19.1 kgs; P < 0.001) than White subjects. HbA 1c levels were higher (6.5 ± 0.7 vs. 6.1 ± 0.6%; P < 0.001) in South Asians compared to Whites. Fasting glucose (5.71 ± 0.5 vs. 5.93 ± 0.7; P = 0.039) was lower in South Asians but 2hour glucose (10.5 ± 1.0 vs. 10.40 ± 0.9; P = 0.404) was similar in both ethnic groups. Conclusion South Asians have higher HbA 1c levels than Whites despite lower fasting glucose value on OGTT, indicating ethnic differences in HbA 1c are due to glycaemia‐independent factors