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Morphological comparison of small nerve fibres in gastric mucosa in non‐diabetic and Type 2 diabetic subjects
Author(s) -
Jin H. Y.,
Kang Y. M.,
Kim C. Y.,
Kim S. H.,
Liu W. J.,
Piao M. H.,
Park J. H.,
Baek H. S.,
Park T. S.
Publication year - 2009
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.2009.02787.x
Subject(s) - medicine , gastric mucosa , diabetes mellitus , biopsy , diabetic neuropathy , immunohistochemistry , type 2 diabetes , gastroenterology , pathology , stomach , endocrinology
Aim To determine changes in small nerve fibres in gastric mucosa in patients with Type 2 diabetes by morphological observation. Methods In twenty‐five non‐diabetic and 21 Type 2 diabetic participants, gastric mucosal biopsy under endoscopy was performed. Innervation in gastric mucosa was detected using immunohistochemical staining. Anti‐protein gene product (PGP) 9.5 positive nerves underwent morphological observation and quantitative analysis. Results Small nerve fibres in gastric mucosa were shortened in the diabetic subjects. The ratio of gastric mucosal protrusions maintaining nerve fibres between gastric pits to total observed protrusions was lower in patients with Type 2 diabetes compared with the non‐diabetic subjects (ratio of innervated protrusion/total protrusion: 0.49 ± 0.12 vs. 0.89 ± 0.06, P < 0.05). Conclusions This study sets the scene for further research to investigate the relationship between gastric mucosal nerves and autonomic neuropathy or diabetic peripheral neuropathy.