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Carotid intima‐media thickness and apolipoprotein B/apolipoprotein A‐I ratio in middle‐aged patients with Type 2 diabetes
Author(s) -
Dahlén E. M.,
Länne T.,
Engvall J.,
Lindström T.,
Grodzinsky E.,
Nystrom F. H.,
Östgren C. J.
Publication year - 2009
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.2009.02693.x
Subject(s) - medicine , apolipoprotein b , odds ratio , diabetes mellitus , type 2 diabetes , endocrinology , intima media thickness , blood pressure , cholesterol , gastroenterology , carotid arteries
Aims To explore the association between carotid intima‐media thickness (IMT) and the apolipoprotein B (apoB)/apolipoprotein A‐I (apoA‐I) ratio compared with conventional lipids in middle‐aged patients with Type 2 diabetes. Methods We analysed data from 247 patients with Type 2 diabetes, aged 55–66 years, in the Cardiovascular Risk factors in Patients with Diabetes—a Prospective study in Primary care (CARDIPP‐1) study. Primary care nurses measured blood pressure and anthropometric characteristics. Blood samples were taken for laboratory analyses. The carotid IMT was determined by ultrasonography at the University Hospital in Linköping and at the County Hospital Ryhov, Jönköping, Sweden. Results The ApoB/apoA‐I ratio ( r = 0.207, P = 0.001), apoB ( r = 0.166, P = 0.009) and non‐high‐density lipoprotein cholesterol (non‐HDL‐c) ( r = 0.129, P = 0.046) correlated with IMT. Conventional lipids, high‐sensitivity C‐reactive protein (hsCRP), glycated haemoglobin (HbA 1c ) and systolic blood pressure were not significantly correlated to IMT. A stepwise logistic regression analysis was conducted with IMT as the dependent variable and the apoB/apoA‐I ratio, HbA 1c , hsCRP, low‐density lipoprotein cholesterol (LDL‐c), total cholesterol, non‐HDL‐c and treatment with statins as independent variables. Following adjustment for age and gender, only the apoB/apoA‐I ratio remained significantly associated with IMT (odds ratio 4.3, 95% confidence intervals 1.7–10.8, P = 0.002). Conclusions We conclude that there was a significant association between the apoB/apoA‐I ratio and IMT in middle‐aged patients with Type 2 diabetes. The association was independent of conventional lipids, hsCRP, glycaemic control and use of statins.