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Hypertriglyceridaemia is associated with an increased likelihood of albuminuria in extreme duration (> 50 years) Type 1 diabetes
Author(s) -
Daousi C.,
Bain S. C.,
Barnett A. H.,
Gill G. V.
Publication year - 2008
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.2008.02534.x
Subject(s) - albuminuria , medicine , diabetes mellitus , creatinine , endocrinology , type 2 diabetes , diabetic nephropathy , nephropathy
Aims To explore the association between dyslipidaemia and albuminuria at the extreme of diabetes duration. Methods Data and samples were collected from 400 patients with extreme duration (> 50 years) of Type 1 diabetes in the UK (Golden Years Cohort). Urinary albumin–creatinine ratio (ACR), glycated haemoglobin (HbA 1c ), creatinine, non‐fasting triglycerides, total cholesterol, high‐density lipoprotein‐ and low‐density lipoprotein‐cholesterol were analysed in all patients. Results Thirty‐six percent of patients had albuminuria (micro‐ or macroalbuminuria). After adjusting for age, gender, HbA 1c , disease duration and presence of macrovascular disease, hypertriglyceridaemia was more likely to be associated with the presence of albuminuria. Conclusions High triglycerides may be a potential risk factor for progression of diabetic nephropathy at the extreme of diabetes duration, but the benefit of targeting this aggressively remains to be evaluated further.