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Does serum 1,5‐anhydroglucitol establish a relationship between improvements in HbA 1c and postprandial glucose excursions? Supportive evidence utilizing the differential effects between biphasic insulin aspart 30 and insulin glargine
Author(s) -
Moses A. C.,
Raskin P.,
Khutoryansky N.
Publication year - 2008
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.2008.02384.x
Subject(s) - postprandial , medicine , endocrinology , insulin glargine , insulin aspart , insulin , diabetes mellitus , type 2 diabetes , glycated hemoglobin
Aim To investigate the relationship between changes in glycated haemoglobin (HbA 1c ) and postprandial glucose excursions on 1,5‐anhydroglucitol (1,5‐AG) in patients with Type 2 diabetes, utilizing the differential effects between biphasic insulin aspart 30 (BIAsp 30) or insulin glargine (IGlar) on postprandial glucose (PPG) levels. Methods 1,5‐AG was measured using the GlycoMark® assay at baseline and after 12 and 28 weeks in the INITiation of Insulin to reach HbA 1c Target (INITIATE) study of 233 patients randomized to either BIAsp 30 or IGlar. Results Baseline 1,5‐AG was low and not significantly different (4.9 ± 3.5 and 4.3 ± 2.6 µg/ml in the BIAsp 30 and IGlar groups, respectively). After 28 weeks, the levels of 1,5‐AG were higher in the BIAsp 30 than in the IGlar group (13.4 vs. 11.1 µg/ml, P = 0.008) and change from baseline was 25% greater with BIAsp 30 than IGlar (8.4 vs. 6.7 µg/ml, P = 0.011). 1,5‐AG levels increased as a function of decreasing HbA 1c or the average change in postprandial plasma glucose (PPG ave ) with significant relationships for 1,5‐AG/ HbA 1c vs. HbA 1c or 1,5‐AG/PPG ave vs. PPG ave (both P < 0.0001), respectively. Conclusions As reported in previous publications, 1,5‐AG reflects ambient glycaemic control and increases with reductions in HbA 1c and postprandial glucose. The greater reductions in postprandial excursion achieved with BiAsp 30 compared with glargine were associated with greater increases in 1,5‐AG. Even moderate elevations in HbA 1c substantially lower 1,5‐AG, suggesting that it can be most discriminating in identifying patients with excessive postprandial glucose excursions at HbA 1c levels that approach the upper end of the normal range.