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Beneficial effects of rosiglitazone on novel cardiovascular risk factors in patients with Type 2 diabetes mellitus
Author(s) -
Kadoglou N. P. E.,
Iliadis F.,
Angelopoulou N.,
Perrea D.,
Liapis C. D.,
Alevizos M.
Publication year - 2008
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.2007.02375.x
Subject(s) - medicine , rosiglitazone , endocrinology , adiponectin , insulin resistance , lipid profile , diabetes mellitus , type 2 diabetes , blood pressure , type 2 diabetes mellitus
Aim Impaired exercise capacity, adiponectin, MMPs and TIMPs have all been implicated in the development of cardiovascular disease. The aim of our study was to determine the effects of rosiglitazone on these factors in diabetic patients. Methods Seventy individuals with Type 2 diabetes were assigned randomly to either a rosiglitazone group (8 mg/day, RG) or a control group (CG) for 6 months. All participants took gliclazide 160 mg plus metformin 1700 mg in stable dose. None of the individuals had diabetic complications or had previously participated in an exercise programme. Anthropometric parameters, VO 2 peak , oxygen pulse, glycaemic indices, lipid profile, adiponectin, insulin resistance, blood pressure and serum MMP‐9, TIMP‐1, TIMP‐2 levels were assessed at baseline and at the end of the study. After Bonferroni adjustment, a P ‐value < 0.017 was assumed to be statistically significant. Results Rosiglitazone treatment significantly increased VO 2 peak ( P < 0.0001), the duration of the exercise test ( P < 0.0001), oxygen pulse ( P = 0.010) and TIMP‐2 levels ( P = 0.008) in comparison with CG. Insulin resistance, hyperglycaemia, diastolic blood pressure and MMP‐9 levels were also reduced ( P < 0.017). Fat mass, lipid profile, TIMP‐1 levels and MMP9 : TIMP‐1 ratio were unaltered after rosiglitazone treatment. There were no significant changes in these parameters in control subjects. In univariate analysis, the rosiglitazone‐induced increment of VO 2 peak was associated with alterations in plasma adiponectin ( r = 0.691), HOMA‐IR ( r = –0.782) and HbA 1c ( r = –0.676) ( P < 0.017). These relationships retained significance after multiple regression analysis ( P = 0.005). Conclusions Rosiglitazone treatment increases cardiorespiratory fitness and modulates favourably serum adiponectin, MMP‐9 and TIMP‐2 levels. Whether these effects produce cardiovascular benefits in the long term requires further investigation.