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An increase in HbA 1c after percutaneous coronary intervention raises the risk for restenosis in patients without Type 2 diabetes mellitus
Author(s) -
Diedrichs H.,
Pfister R.,
Hagemeister J.,
MüllerEhmsen J.,
Frank K. F.,
Höpp H.W.,
Erdmann E.,
Schneider C. A.
Publication year - 2008
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.2007.02320.x
Subject(s) - medicine , restenosis , conventional pci , percutaneous coronary intervention , diabetes mellitus , cardiology , odds ratio , coronary angiography , angiography , myocardial infarction , endocrinology , stent
Aims The influence of dynamic changes in glycated haemoglobin (HbA 1c ) on restenosis after elective percutaneous coronary intervention (PCI) in patients without diabetes has not been analysed. Therefore, the rate of restenosis was investigated after elective PCI in 101 consecutive patients without diabetes mellitus in relation to dynamic changes of HbA 1c levels. Methods Follow‐up angiography was performed in all patients 4–6 months after intervention. Results Multivariate analysis demonstrated that the change in HbA 1c between first and second coronary angiography was the most powerful metabolic parameter for prediction of restenosis. The odds ratio for restenosis was 3.0 (95% CI 1.0–9.0) for any increase in HbA 1c and 1.9 (95% CI 1.1–3.5) for an HbA 1c increase of 0.2%. Conclusions Hence, chronic changes in the glucometabolic environment influence the incidence of restenosis after PCI in patients without diabetes.