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Prevailing therapeutic regimes and predictive factors for prandial insulin substitution in 26 687 children and adolescents with Type 1 diabetes in Germany and Austria
Author(s) -
Knerr I.,
Hofer S. E.,
Holterhus P. M.,
Näke A.,
Rosenbauer J.,
Weitzel D.,
Wolf J.,
Holl R. W.
Publication year - 2007
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.2007.02273.x
Subject(s) - medicine , type 2 diabetes , substitution (logic) , diabetes mellitus , insulin , endocrinology , computer science , programming language
Aims To analyse current therapeutic strategies for prandial insulin substitution in a large number of children and adolescents with Type 1 diabetes in Germany and Austria, along with changes in therapeutic habits and outcome. Methods We classified the data of 26 687 patients, treated from 1995 to 2005 in 152 paediatric clinics, using a database established for quality control and scientific surveys in paediatric diabetology (DPV). Results Seventy‐three per cent of all patients (mean age 13.6 years., mean duration of diabetes 5.4 years.) were treated with ≥ 4 daily injections (intensified conventional treatment; ICT), 14% with continuous subcutaneous insulin infusion (CSII), 13% with 1–3 injections per day (conventional treatment). Frequency of daily injections increased with age, duration of diabetes and insulin dose. The insulin dose at breakfast was higher than for the evening meal or lunch, from diagnosis onwards. Individuals using insulin analogues received up to 11% higher insulin doses per day compared with patients treated with human insulin. The time of day, age, duration of diabetes, female gender, insulin analogues and ICT all had a significant influence on prandial insulin doses. Although the number of patients treated with ICT or CSII increased over the period of observation, mean glycated haemoglobin (HbA 1c ) was approximately 8.0% each year, and decreased by only 0.01%. Conclusions Eighty‐seven per cent of patients were treated with ICT or CSII. However, while this percentage increased over the observation period, mean HbA 1c was almost constant. Longer duration of diabetes, increasing age, female gender, insulin analogues and ICT were associated with higher prandial insulin doses.